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The Methuen Drama Book of Contemporary Japanese Plays - The Bacchae-Holstein Milk Cows; One Night; Isn't Anyone Alive?;... The Methuen Drama Book of Contemporary Japanese Plays - The Bacchae-Holstein Milk Cows; One Night; Isn't Anyone Alive?; The Sun; Carcass (Paperback)
Yuko Kuwabara, Takuya Yokoyama, Shiro Maeda, Satoko Ichihara, Tomohiro Maekawa
R791 Discovery Miles 7 910 Ships in 12 - 17 working days

Published alongside The Japan Foundation, this collection features five creative and bold plays by some of Japan's most prolific writers of contemporary theatre. Translated into English for the first time, these texts explore a wide range of themes from dystopian ideas of the future to touching domestic tragedies. Brought together in one volume, introduced by the authors and The Japan Foundation, this collection offers English language readers an unprecedented look at some of Japan's finest works of contemporary drama by writers from across the country. The plays include: The Bacchae-Holstein Milk Cows by Satoko Ichihara (Translated by Aya Ogawa) This play takes themes of the ancient Greek tragedy Bacchae by Euripides to examine various aspects of contemporary society, from love and sex, man and woman, intermixture of different species, discrimination and abuse, to artificial insemination, criticism of anthropocentricism and more. It was the winner of the 64th Kishida Drama Award. One Night by Yuko Kuwabara (Translated by Mari Boyd) The setting is a small taxi company run out of the home of its owner in a country town. One night the mother, Koharu Inamura, decides to leave the home in order to protect her children from her husband's domestic violence, promising them that she will come back in 15 years. The play depicts the family's reunion after having to live with the burden of that one night's (hitoyo) incident and how they restarted their lives after it. Isn't Anyone Alive? by Shiro Maeda (Translated by Miwa Monden) This laid back, absurdist work examines death through a goofy lens. In the play, strange urban legends abound in a university hospital where young people die one after another, all with mobile phones in their hands. The Sun by Tomohiro Maekawa (Translated by Nozomi Abe) Depicts young people torn apart in a near future setting where humanity has split into two forms: Nox humans who can only go out at night, and Curios, the original type of humans that can live under the sun. Carcass by Takuya Yokoyama (Translated by Mari Boyd) This play takes its name from the Japanese word for dressed carcasses of beef and pork that have been halved along the backbone for meat . It deals with the dignity of being alive as seen through the lives of workers in the meat industry based on interviews and research. It won the Japan Playwrights Association's 15th New Playwright Award in 2009.

Cleaning: Kenya Hara Cleaning
Kenya Hara; As told to MUJI; Text written by Takuya Seki, Mariko Hara; Photographs by Yoshihiko Ueda, …
R667 Discovery Miles 6 670 Ships in 12 - 17 working days

Cleanliness is a core value of societies around the globe. So much so that cleaning seems to be an inherent part of human nature and how we interact with and domesticate our environment. This book explores the concept of cleaning in all its various aspects and illustrates each cleaning method, thus expanding our conception of an activity that is such a big part of our daily lives. From a child sorting its toys, to the meticulous work of a clockmaker and an impressive deep-clean of a ship, each process is treated with the same gentle fascination. Short texts add a semi-poetic dimension. The portable book format invites readers to take this publication out into the world with them as they look at everyday processes with fresh eyes. Flipping through the pages of Cleaning is as enlightening as it is entertaining.

Nanotechnology Commercialization (Hardcover): Takuya Tsuzuki Nanotechnology Commercialization (Hardcover)
Takuya Tsuzuki
R2,396 Discovery Miles 23 960 Ships in 12 - 17 working days

In terms of commercialization, nanomaterials occupy a unique place in nanotechnology. Engineered nanomaterials, especially nanoparticulate materials, are the leading sector in nanotechnology commercialization. In addition, the nanomaterial sector has attracted much more heated debate than any other nanotechnology sector with regard to safety, regulation, standardization, and ethics. This is the first book on nanotechnology commercialization that deals exclusively with nanomaterials. It provides overviews of the current trends in, and the issues associated with, the commercialization of nanomaterials by some of the foremost nanotechnology experts in their fields.

The Realizations of the Self (Hardcover, 1st ed. 2018): Andrea Altobrando, Takuya Niikawa, Richard Stone The Realizations of the Self (Hardcover, 1st ed. 2018)
Andrea Altobrando, Takuya Niikawa, Richard Stone
R3,391 Discovery Miles 33 910 Ships in 12 - 17 working days

Recent discussions of self-realization have devolved into unscientific theories of self-help. However, this vague and often misused concept is connected to many important individual and social problems. As long as its meaning remains unclear, it can be abused for social, political, and commercial malpractices. To combat this issue, this book shares perspectives from scholars of various philosophical traditions. Each chapter takes new steps in asking what the meaning of self-realization is-both in terms of what it means to understand who or what one is, and also in terms of how one can, or should, fulfilll oneself. The conceptual elucidations achieved from both theoretical and practical perspectives allow for a more mature awareness of how to deal with discourses on self-realization and, in any case, can help to demystify the subject.

Current Issues in Public Utilities and Public Policy - Empirical Studies Focusing on Japan (Hardcover, 1st ed. 2023): Fumitoshi... Current Issues in Public Utilities and Public Policy - Empirical Studies Focusing on Japan (Hardcover, 1st ed. 2023)
Fumitoshi Mizutani, Takuya Urakami, Eri Nakamura
R4,283 Discovery Miles 42 830 Ships in 12 - 17 working days

This book is novel in that it reveals significant issues of economics, management and business fields currently observed in network industries such as public utilities and transportation, and provides empirical evidence of their mechanisms and policy implications from various perspectives. This is a holistic collection of literature on public utilities economics and management, since the industries discussed include a wide range such as electricity, water supply, sewerage, transport, and postal service, which compound social infrastructure as public benefit service, and the issues examined contain not only economics topics such as cost, efficiency, and productivity, but also management topics such as governance, strategy and organizational restructuring. The book also investigates general private companies to derive future implications for policy and governance of public utilities, and covers multiple countries such as Japan, the US, and Vietnam. It demonstrates various empirical approaches and methodologies for public utility analysis through 17 chapters by experts in each field, which contributes to further cultivation of empirical studies in public utilities.

The Realizations of the Self (Paperback, Softcover reprint of the original 1st ed. 2018): Andrea Altobrando, Takuya Niikawa,... The Realizations of the Self (Paperback, Softcover reprint of the original 1st ed. 2018)
Andrea Altobrando, Takuya Niikawa, Richard Stone
R2,703 Discovery Miles 27 030 Ships in 10 - 15 working days

Recent discussions of self-realization have devolved into unscientific theories of self-help. However, this vague and often misused concept is connected to many important individual and social problems. As long as its meaning remains unclear, it can be abused for social, political, and commercial malpractices. To combat this issue, this book shares perspectives from scholars of various philosophical traditions. Each chapter takes new steps in asking what the meaning of self-realization is-both in terms of what it means to understand who or what one is, and also in terms of how one can, or should, fulfilll oneself. The conceptual elucidations achieved from both theoretical and practical perspectives allow for a more mature awareness of how to deal with discourses on self-realization and, in any case, can help to demystify the subject.

Haptic Interaction - Science, Engineering and Design (Paperback, Softcover reprint of the original 1st ed. 2018): Shoichi... Haptic Interaction - Science, Engineering and Design (Paperback, Softcover reprint of the original 1st ed. 2018)
Shoichi Hasegawa, Masashi Konyo, Ki-Uk Kyung, Takuya Nojima, Hiroyuki Kajimoto
R5,829 Discovery Miles 58 290 Ships in 10 - 15 working days

This book comprises the proceedings of the second International Conference, AsiaHaptics 2016, held in Kashiwanoha, Japan. The book treats the state of the art of the diverse haptics (touch)-related research, including scientific research of haptics perception and illusion, development of haptics devices, and applications to a wide variety of fields such as education, medicine, telecommunication, navigation, and entertainment. This work helps not only active haptic researchers, but also general readers to understand what is going on in this interdisciplinary area of science and technology.

Mid-size Drugs Based on Peptides and Peptidomimetics - A New Drug Category (Paperback, 1st ed. 2018): Hirokazu Tamamura, Takuya... Mid-size Drugs Based on Peptides and Peptidomimetics - A New Drug Category (Paperback, 1st ed. 2018)
Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi
R1,557 Discovery Miles 15 570 Ships in 10 - 15 working days

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.

Haptic Interaction - Science, Engineering and Design (Hardcover, 1st ed. 2018): Shoichi Hasegawa, Masashi Konyo, Ki-Uk Kyung,... Haptic Interaction - Science, Engineering and Design (Hardcover, 1st ed. 2018)
Shoichi Hasegawa, Masashi Konyo, Ki-Uk Kyung, Takuya Nojima, Hiroyuki Kajimoto
R7,568 Discovery Miles 75 680 Ships in 10 - 15 working days

This book comprises the proceedings of the second International Conference, AsiaHaptics 2016, held in Kashiwanoha, Japan. The book treats the state of the art of the diverse haptics (touch)-related research, including scientific research of haptics perception and illusion, development of haptics devices, and applications to a wide variety of fields such as education, medicine, telecommunication, navigation, and entertainment. This work helps not only active haptic researchers, but also general readers to understand what is going on in this interdisciplinary area of science and technology.

Cell-Free Protein Production - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2010): Yaeta Endo,... Cell-Free Protein Production - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2010)
Yaeta Endo, Kazuyuki Takai, Takuya Ueda
R3,752 Discovery Miles 37 520 Ships in 10 - 15 working days

During the past decade as the data on gene sequences and expression patterns rapidly accumulated, cell-free protein synthesis technology has also experienced a revolution, becoming a powerful tool for the preparation of proteins for their functional and structural analysis. In Cell-Free Protein Production: Methods and Protocols, experts in the field contribute detailed techniques, the uses of which expand deep into the studies of biochemistry, molecular biology, and biotechnology. Beginning briefly with basic methods and historical aspects, the book continues with thorough coverage of protein preparation methods, the preparation of proteins that are generally difficult to prepare in their functional forms, applications of the cell-free technologies to protein engineering, as well as some methods that are expected to constitute a part of future technologies. Written in the highly successful Methods in Molecular Biology (TM) series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cell-Free Protein Production: Methods and Protocols aims to help researchers continue the growth of the vital exploration of cell-free sciences and technologies in order to better understand the dynamic lives of cells.

Film Silicon Science and Technology: Volume 1536 (Hardcover): Paul Stradins, Akram Boukai, Friedhelm Finger, Takuya Matsui,... Film Silicon Science and Technology: Volume 1536 (Hardcover)
Paul Stradins, Akram Boukai, Friedhelm Finger, Takuya Matsui, Nicolas Wyrsch
R1,558 Discovery Miles 15 580 Ships in 12 - 17 working days

Symposium A, Film Silicon Science and Technology, was held April 1 5th, 2013 at the 2013 MRS Spring Meeting in San Francisco, California."

Impact Assessment for Developing Countries - A Guide for Government Officials and Public Servants (Hardcover, 1st ed. 2022):... Impact Assessment for Developing Countries - A Guide for Government Officials and Public Servants (Hardcover, 1st ed. 2022)
Takuya Nakaizumi
R652 Discovery Miles 6 520 Ships in 12 - 17 working days

Impact Assessment (IA) is introduced in this book, with a guide to the process, scope, content, and management of IA for the governments of developing economies. In doing so, evidence-based policy making is taken into full consideration. After the principles of IA are set forth, its procedures are described, illustrated by typical cases from the United States and Japan. Then an explanation follows of the components of IA such as necessity, alternatives, and assessment of cost and benefit, with a description of competition assessment. In developing economies, it is not effective to simply import a system from developed countries directly into developing countries, especially for economic regulation and in consideration of compliance and competition issues. Thus the book provides recommendations on how to appropriately modify developed countries' systems for countries that are still developing. The book concludes by taking up several issues surrounding IA, especially nudge theory and public involvement.

Dirac Spectra in Dense QCD (Paperback, 2013 ed.): Takuya Kanazawa Dirac Spectra in Dense QCD (Paperback, 2013 ed.)
Takuya Kanazawa
R3,372 Discovery Miles 33 720 Ships in 10 - 15 working days

Gaining a theoretical understanding of the properties of ultra-relativistic dense matter has been one of the most important and challenging goals in quantum chromodynamics (QCD). In this thesis, the author analyzes dense quark matter in QCD with gauge group SU(2) using low-energy effective theoretical techniques and elucidates a novel connection between statistical properties of the Dirac operator spectrum at high baryon chemical potential and a special class of random matrix theories. This work can be viewed as an extension of a similar correspondence between QCD and matrix models which was previously known only for infinitesimal chemical potentials. In future numerical simulations of dense matter the analytical results reported here are expected to serve as a useful tool to extract physical observables such as the BCS gap from numerical data on the Dirac spectrum.

Dirac Spectra in Dense QCD (Hardcover, 2013 ed.): Takuya Kanazawa Dirac Spectra in Dense QCD (Hardcover, 2013 ed.)
Takuya Kanazawa
R3,615 Discovery Miles 36 150 Ships in 10 - 15 working days

Gaining a theoretical understanding of the properties of ultra-relativistic dense matter has been one of the most important and challenging goals in quantum chromodynamics (QCD). In this thesis, the author analyzes dense quark matter in QCD with gauge group SU(2) using low-energy effective theoretical techniques and elucidates a novel connection between statistical properties of the Dirac operator spectrum at high baryon chemical potential and a special class of random matrix theories. This work can be viewed as an extension of a similar correspondence between QCD and matrix models which was previously known only for infinitesimal chemical potentials. In future numerical simulations of dense matter the analytical results reported here are expected to serve as a useful tool to extract physical observables such as the BCS gap from numerical data on the Dirac spectrum.

Biodiversity - An Ecological Perspective (Paperback, Softcover reprint of the original 1st ed. 1997): Takuya Abe, Simon A.... Biodiversity - An Ecological Perspective (Paperback, Softcover reprint of the original 1st ed. 1997)
Takuya Abe, Simon A. Levin, Masahiko Higashi
R2,961 Discovery Miles 29 610 Ships in 10 - 15 working days

Despite acknowledgment that loss of living diversity is an international biological crisis, the ecological causes and consequences of extinction have not yet been widely addressed. In honor of Edward O. Wilson, winner of the 1993 International Prize for Biology, an international group of distinguished biologists bring ecological, evolutionary, and management perspectives to the issue of biodiversity. The roles of ecosystem processes, community structure and population dynamics are considered in this book. The goal, as Wilson writes in his introduction, is "to assemble concepts that unite the disciplines of systematics and ecology, and in so doing to create a sound scientific basis for the future management of biodiversity."

Permafrost Ecosystems - Siberian Larch Forests (Paperback, 2010 ed.): Akira Osawa, Olga A. Zyryanova, Yojiro Matsuura, Takuya... Permafrost Ecosystems - Siberian Larch Forests (Paperback, 2010 ed.)
Akira Osawa, Olga A. Zyryanova, Yojiro Matsuura, Takuya Kajimoto, Ross W. Wein
R5,831 Discovery Miles 58 310 Ships in 10 - 15 working days

Drawing from a decade-long collaboration between Japan and Russia, this important volume presents the first major synthesis of current knowledge on the ecophysiology of the coniferous forests growing on permafrost at high latitudes. It presents ecological data for a region long inaccessible to most scientists, and raises important questions about the global carbon balance as these systems are affected by the changing climate.

Making up around 20% of the entire boreal forests of the northern hemisphere, these permafrost forest ecosystems are subject to particular constraints in terms of temperature, nutrient availability, and root space, creating exceptional ecosystem characteristics not known elsewhere. This authoritative text explores their diversity, structure, dynamics and physiology. It provides a comparison of these forests in relation to boreal forests elsewhere, and concludes with an assessment of the potential responses of this unique biome to climate change.

The book will be invaluable to advanced students and researchers interested in boreal vegetation, forest ecology, silviculture and forest soils, as well as to researchers into climate change and the global carbon balance. "

Chemistry of Nanomolecular Systems - Towards the Realization of Molecular Devices (Paperback, Softcover reprint of hardcover... Chemistry of Nanomolecular Systems - Towards the Realization of Molecular Devices (Paperback, Softcover reprint of hardcover 1st ed. 2003)
Takayoshi Nakamura, Takuya Matsumoto, Hirokazu Tada, Ken-Ichi Sugiura
R2,934 Discovery Miles 29 340 Ships in 10 - 15 working days

Recently, molecular electronics, especially that utilizing single molecules, has been attracting much attention. This is mainly because the theoretical limit is approaching in the present silicon-based technology, and the development of an alternative process is strongly desired. Single-molecule electronics is aimed at a breakthrough toward the next generation of computing systems. By designing and synthesizing highly functionalized molecules of nanometer size and incorporating these molecules into electrical circuits, we shall obtain much dense and high-speed processors. The concept of single-molecule electronics was first introduced by Aviram and Ratnar in 1978. In the early 1980s, many groups all over the world had started research on molecular electronics. At that time, single-molecule manipulation techniques had not been born, and the research was mainly carried out on molecular films formed by the Langmuir Blodgett technique, a wet process, and by molecular-beam epitaxy, a dry process. A number of prototypes of switching devices and logic gates were, however, reported in the 1980s. In the early 1990s, scanning probe microscopes became popular and researchers obtained a single-molecule manipulation and evaluation tech nique. It became possible to fabricate practical devices using single molecules or small numbers of molecules. Finally, at the end of the last century, an explosion in the research field of single-molecule electronics was witnessed. In addition, studies of "biocomputing" started in the early 1980s and significant progress was achieved in the last century."

Permafrost Ecosystems - Siberian Larch Forests (Hardcover, 2010 ed.): Akira Osawa, Olga A. Zyryanova, Yojiro Matsuura, Takuya... Permafrost Ecosystems - Siberian Larch Forests (Hardcover, 2010 ed.)
Akira Osawa, Olga A. Zyryanova, Yojiro Matsuura, Takuya Kajimoto, Ross W. Wein
R5,884 Discovery Miles 58 840 Ships in 10 - 15 working days

Drawing from a decade-long collaboration between Japan and Russia, this important volume presents the first major synthesis of current knowledge on the ecophysiology of the coniferous forests growing on permafrost at high latitudes. It presents ecological data for a region long inaccessible to most scientists, and raises important questions about the global carbon balance as these systems are affected by the changing climate.

Making up around 20% of the entire boreal forests of the northern hemisphere, these permafrost forest ecosystems are subject to particular constraints in terms of temperature, nutrient availability, and root space, creating exceptional ecosystem characteristics not known elsewhere. This authoritative text explores their diversity, structure, dynamics and physiology. It provides a comparison of these forests in relation to boreal forests elsewhere, and concludes with an assessment of the potential responses of this unique biome to climate change.

The book will be invaluable to advanced students and researchers interested in boreal vegetation, forest ecology, silviculture and forest soils, as well as to researchers into climate change and the global carbon balance. "

Cell-Free Protein Production - Methods and Protocols (Hardcover, 2010 ed.): Yaeta Endo, Kazuyuki Takai, Takuya Ueda Cell-Free Protein Production - Methods and Protocols (Hardcover, 2010 ed.)
Yaeta Endo, Kazuyuki Takai, Takuya Ueda
R3,027 Discovery Miles 30 270 Ships in 10 - 15 working days

During the past decade as the data on gene sequences and expression patterns rapidly accumulated, cell-free protein synthesis technology has also experienced a revolution, becoming a powerful tool for the preparation of proteins for their functional and structural analysis. In Cell-Free Protein Production: Methods and Protocols, experts in the field contribute detailed techniques, the uses of which expand deep into the studies of biochemistry, molecular biology, and biotechnology. Beginning briefly with basic methods and historical aspects, the book continues with thorough coverage of protein preparation methods, the preparation of proteins that are generally difficult to prepare in their functional forms, applications of the cell-free technologies to protein engineering, as well as some methods that are expected to constitute a part of future technologies. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Cell-Free Protein Production: Methods and Protocols aims to help researchers continue the growth of the vital exploration of cell-free sciences and technologies in order to better understand the dynamic lives of cells.

Chemistry of Nanomolecular Systems - Towards the Realization of Molecular Devices (Hardcover, 2003 ed.): Takayoshi Nakamura,... Chemistry of Nanomolecular Systems - Towards the Realization of Molecular Devices (Hardcover, 2003 ed.)
Takayoshi Nakamura, Takuya Matsumoto, Hirokazu Tada, Ken-Ichi Sugiura
R3,090 Discovery Miles 30 900 Ships in 10 - 15 working days

This book describes contemporary efforts to develop nano-molecular systems for future molecular electronics in which single molecules act as the basic elements in electrical circuits. While describing frontier research, it also gives a comprehensive introduction and discusses the related work being pursued worldwide. The book is composed of three parts. The first part describes the synthesis of novel molecules for molecular nano-systems. The second part deals mainly with nano-molecular systems on solid surfaces and the evaluation of the system with SPM. The third part reviews the theory required as a background for molecular electronics.

Worldwide Computing and Its Applications - WWCA'98 - Second International Conference, Tsukuba, Japan, March 4-5, 1998,... Worldwide Computing and Its Applications - WWCA'98 - Second International Conference, Tsukuba, Japan, March 4-5, 1998, Proceedings (Paperback, 1998 ed.)
Yoshifumi Masunaga, Takuya Katayama, Michiharu Tsukamoto
R1,783 Discovery Miles 17 830 Ships in 10 - 15 working days

This book constitutes the refereed proceedings of the Second International Conference on Worldwide Computing and Its Applications, WWCA'98, held in Tsukuba, Japan, in March 1998.
This volume presents 14 invited and survey papers together with 20 papers selected by the conference committee. The volume is divided into topical sections on distributed objects, distributed componentware, distributed systems platforms, Internet technology, mobile computing, interculture technology, collaborative media, collaborative support, information discovery and retrieval, novel network applications.

Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases (Paperback, 1st ed. 2022): Takuya Hidaka Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases (Paperback, 1st ed. 2022)
Takuya Hidaka
R4,431 Discovery Miles 44 310 Ships in 10 - 15 working days

This book describes the author's work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole-imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells. This work will attract readers' interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author's studies and to perform similar and extended studies themselves.

Abscisic Acid - Methods and Protocols (Hardcover, 1st ed. 2022): Takuya Yoshida Abscisic Acid - Methods and Protocols (Hardcover, 1st ed. 2022)
Takuya Yoshida
R6,568 Discovery Miles 65 680 Ships in 10 - 15 working days

This volume presents an all-inclusive overview of molecular biological methods to study ABA signaling transport, and metabolism in several plant species. The chapters in this book cover topics such as biochemical and molecular biological characterization of ABA receptors; assay systems for ABA transporters; quantification and visualization of ABA levels; and comprehensive omics approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Abscisic Acid: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this developing field.

Discovery Science - 20th International Conference, DS 2017, Kyoto, Japan, October 15-17, 2017, Proceedings (Paperback, 1st ed.... Discovery Science - 20th International Conference, DS 2017, Kyoto, Japan, October 15-17, 2017, Proceedings (Paperback, 1st ed. 2017)
Akihiro Yamamoto, Takuya Kida, Takeaki Uno, Tetsuji Kuboyama
R2,665 Discovery Miles 26 650 Ships in 10 - 15 working days

This book constitutes the proceedings of the 20th International Conference on Discovery Science, DS 2017, held in Kyoto, Japan, in October 2017, co-located with the International Conference on Algorithmic Learning Theory, ALT 2017. The 18 revised full papers presented together with 6 short papers and 2 invited talks in this volume were carefully reviewed and selected from 42 submissions. The scope of the conference includes the development and analysis of methods for discovering scientific knowledge, coming from machine learning, data mining, intelligent data analysis, big data analysis as well as their application in various scientific domains. The papers are organized in topical sections on machine learning: online learning, regression, label classification, deep learning, feature selection, recommendation system; and knowledge discovery: recommendation system, community detection, pattern mining, misc.

Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases (Hardcover, 1st ed. 2022): Takuya Hidaka Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases (Hardcover, 1st ed. 2022)
Takuya Hidaka
R3,697 Discovery Miles 36 970 Ships in 12 - 17 working days

This book describes the author's work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole-imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells. This work will attract readers' interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author's studies and to perform similar and extended studies themselves.

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